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Popular Antidepressants Linked to GI Bleeding

August 1, 2008

The widely prescribed class of antidepressants known as SSRIs may be associated with bleeding in the upper gastrointestinal tract, especially when taken with painkillers called nonsteroidal anti-inflammatory drugs, a new study says.

Although reports of this effect from the selective serotonin reuptake inhibitors family of antidepressants — which includes Prozac, Paxil and Zoloft — have been noted before, some outside experts said the evidence is still far from conclusive.

“Certainly, doctors should be advising patients of this finding, but it’s far from definitive,” said Dr. Ewald Horwath, professor of psychiatry, epidemiology and public health at the University of Miami Miller School of Medicine. “The risk of discontinuing antidepressants and getting depression and its consequences are much greater than this drug.”

But, other experts said that the public health impact of the new finding, if confirmed, could be significant.

Read Article Washington Post

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